Cytoplasmic microtubules in blood platelets.
نویسندگان
چکیده
منابع مشابه
Incomplete Microtubules Observed in Mammalian Blood Platelets during Microtubule Polymerization
and 0°C. In both cases the process was reversible (1), 1 the microtubules reappearing when the cold treatment was discontinued. This work deals with the cytoplasmic microtubules in mammalian blood platelets. Unlike the microtubules of the axial filament complex of cilia and flagella, these microtubules are properly preserved only by glutaraldehyde fixation. In platelets the microtubules are arr...
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The mechanism of platelet release has been studied in mouse bone marrow, using scanning and transmission electron microscopy. Cytoplasmic processes extended into sinusoids by megakaryocytes were found to undergo attenuation, and at the distal end develop constrictions between segments of platelet size. Rupture at sites of constriction is thought to release platelets. Microtubules were present i...
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Human blood platelets were subjected to osmotic shock, brief sonication, pressure homogenization, or treatment with adenosine diphosphate (ADP). These procedures demonstrated an abundance of cytoplasmic microfibrils. The fibrils resembled those found on electron microscopy of partially purified thrombosthenin, the actomyosin-like protein isolated from platelets, and they also appeared to resemb...
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The increasing frequency with which microtubules are observed in electron micrographs of many cell types has led to much speculation about the possible structural and functional significance of these cytoplasmic elements. Two basic interpretations have been made: that they serve as cytoskeletal elements has been suggested by the work of many investigators (3, 4, 5, 9, 10, 12, 16-18); that they ...
متن کاملMicrotubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.
Bone marrow megakaryocytes produce platelets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels. Although microtubules are known to regulate platelet production, the underlying mechanism of proplatelet elongation has yet to be resolved. Here we report that proplatelet formation is a process that can be divided into repetitive phases (extension, pau...
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عنوان ژورنال:
- Blood
دوره 27 2 شماره
صفحات -
تاریخ انتشار 1966